Archive for the ‘Dermatology’ Category
Suprabasal and Granular cell layer
The suprabasal cell layer is composed of five to ten layers that appear connected to each other by prickle-like structures. Suprabasal (prickle) cells are polygonal in the lower layer and flattened in the upper layers. They are larger than basal cells and contain a small amount of chromatin in their circular nucleus.
The part that gives the appearance of a prickle corresponds to the desmosome (a form of intercellular bridge).
The granular cell layer is composed of two or three layers of cells containing basophilic keratohyalin granules. The cells and nuclei in the granular cell layers are even flatter than those in the suprabasal layer. Spherical lamellar granules, each with a diameter of approximately 300 nm (also known as Odland bodies or
ketatosomes), can be observed in the granular cell layers by electron microscopy. The main component of lamellar granules is released into the intercellular space of horny cells as stratum corneum lipid.